The 21st International Symposium on Pediatric Neuro-Oncology was held June 28-July 2, 2024 in Philadelphia, Pennsylvania. ISPNO is the major global meeting for the international community of professionals involved in the scientific research, diagnosis, treatment, and rehabilitation of kids and teens with brain and central nervous system cancers.
Doctors, researchers, and nurses you support from the Morgan Adams Foundation Pediatric Brain Tumor Research Program and Children’s Hospital Colorado had 21 abstracts selected for presentation at ISPNO 2024. Of those, 12 were chosen for coveted and highly respected oral presentations during the three-day scientific conference.
Combinatorial BH3-mimetic strategy for overcoming radioresistance in pediatric high-grade glioma
Krishna Madhavan, Sahiti Donthula, Faye M Walker, Lays Martin Sobral, Ilango Balakrishnan, Angela Pierce, Sana D Karam, Natalie J Serkova, Sujatha Venkataraman, Nathan A Dahl
^BH3 Mimetics Improve Response to Autophagy Inhibition in BRAFV600E Gliomas
Michele Crespo, Shadi Zahedi, Andrew Morin, Darya Wodetzski, Madeline Groat, Emil Bratbak, Kendra Jones, Andrea Griesinger, Cecilia Caino, Jean Mulcahy Levy
Characterization of spontaneous canine high-grade glioma models as clinically-relevant surrogates of pediatric high-grade glioma
Gabrielle Link, Simon Garey, John DeSisto, Markos Antonakakis, Stephanie McGrath, Lyndah Chow, Mathew Slade, Steven Dow, Adam L Green
*PRC1/BMI1 activity alters chromatin accessibility to regulate differentiation in Atypical Teratoid Rhabdoid Tumors
Irina Alimova, Gillian Murdock, Angela M Pierce, Etienne Danis, Dong Wang, Natalie Serkova, Nicholas Foreman, Nathan Dahl, Sujatha Venkataraman, Rajeev Vibhakar
*Cell surface proteome analysis of ATRT identifies CD44V6 as a CAR Target
Allison Cole, Eric Hoffmeyer, Enrique Grimaldo, Andrew Donson, Rajeev Vibhakar, Anandani Nellan, Siddhartha S Mitra
*The role of the advanced practice provider in the paired normal specimen process at a tertiary care center
Molly S Hemenway, Shelby Winzent-Oonk
*Medical Aid in Dying: Experience in the Center for Cancer and Blood Disorders at Children’s Hospital Colorado
Shelby Winzent-Oonk, Chelsea Vallejos, Molly Hemenway, Holly B. Lindsay, Adam L. Green
Identification of 5-flurouracil as a selective therapy in a novel EP300::BCOR fusion glioma tumor model
Andrew M Donson, Vladimir Amani, Andrea M Griesinger, Annaliese Calzadilla, Enrique Grimaldo, Nicholas Willard, Nicholas K Foreman, Jean Mulcahy-Levy
Combined preclinical and clinical investigation of which pediatric high-grade glioma subtypes benefit from CCNU/temozolomide
Rebecca D Haase, Lindsay Kilburn, Mariella Filbin, Adam L Green
User Evaluation of an AI-Powered Web Application to Support Radiographic Interpretation of Patients with Adamantinomatous Craniopharyngioma
Eric W Prince, David M Mirsky, Carsten Görg, Todd C. Hankinson
Innate Immune Evasion in MYC-Amplified Medulloblastoma
Jeremy Vo, Juni S Mitra, Aaron Knox, Daniel Picard, Rajeev Vibhakar, Todd Hankinson, Siddhartha S Mitra
Synergistic Targeting of CDK8 and mTOR for MYC-Driven Medulloblastoma
Bethany Veo, Eric Prince, Dong Wang, Andrew Goodspeed, and Rajeev Vibhakar
Dual targeting of processive transcription for Myc-driven circuitry in medulloblastoma
Faye M Walker, Krishna Madhavan, Lays Martin Sobral, Sahiti Donthula, Ilango Balakrishnan, Dong Wang, Angela Pierce, Bethany Veo, Sana D Karam, Natalie J Serkova, Nicholas K Foreman, Sujatha Venkataraman, Rajeev Vibhakar, Nathan A Dahl
*Exploration of tumor suppressor LATS1 loss in posterior fossa group A ependymoma with loss of chromosome 6q
Andrew M Donson, Andrea M Griesinger, Annaliese Calzadilla, Vladimir Amani, Enrique Grimaldo, Nicholas K Foreman
*Targeting Trisomy MDM4 Induces Cell Death in 1q+ PFA Ependymoma Through Reactivation of the p53 Pathway
Annaliese J. Calzadilla, Andrea M. Griesinger, Andrew M. Donson, Enrique Grimaldo, Krishna Madhavan, Irina Alimova, Angela M. Pierce, Breauna Brunt, Rajeev Vibhakar, Nicholas K. Foreman
*5FU sensitivity is mediated through trisomy UCK2 expression in 1q+ PFA EPN
Andrea M Griesinger, Annaliese J Calzadilla, Enrique Grimaldo, Andrew M Donson, Vladimir Amani, Angela M Pierce, Jena Steiner, Soudabeh Kargar, Natalie J Serkova, Kelsey C Bertrand, Karen D Wright, Rajeev Vibhakar, Todd Hankinson, Michael Handler, Holly B Lindsay, Nicholas K Foreman, Kathleen Dorris
*Pediatric radiation-induced glioma patient samples and novel patient-derived models reveal translationally relevant treatment susceptibilities and potential germline risk factors
John DeSisto, Aaron Knox, Mathew Slade, Gabrielle Link, Yonghua Zhuang, Andrew Donson, Kristen Miller, Elinor Barsh, Michael Arnold, Gregory T Armstrong, Smita Bhatia, Sana D Karam, Natalie Serkova, Rajeev Vibhakar, Nicholas Foreman, Adam L Green
*Does Pre-Irradiation Gross Tumor Volume Predict the Risk of Progression after Radiation Therapy in Pediatric Patients with Adamantinomatous Craniopharyngioma?
Tamar Brooks, Dexiang Gao, Katie Dorris, David M Mirsky, Susan Staulcup, Eric Prince, Marina Moskalenko, Elizabeth Ignowski, Narine Wandrey, Kareem Fakhoury, Todd C Hankinson, Sarah A Milgrom
*Phase 0 and feasibility single-institution clinical trial of intravenous tocilizumab for adamantinomatous craniopharyngioma
Kathleen Dorris, Ashley Mettetal, Molly Hemenway, Shelby Winzent-Oonk, Nathan Dahl, Jean Mulcahy Levy, Eric Prince, Jennifer McWilliams, Kimberly R Jordan, David Mirsky, Lindsey Hoffman, Todd Hankinson
*Proteomic analysis of Adamantinomatous Craniopharyngioma reveals a complex network of ECM remodeling
Aaron Knox, Stephen Medlin, Keanu Chee, Susan Staulcup, Eric W Prince, Todd C. Hankinson, Siddhartha Mitra
*Biological Background and Current State of Clinical Trials for Childhood Craniopharyngioma
Todd C. Hankinson
* Denotes oral presentation
^ Denotes winner
Underlined name denotes presenter
