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2026 Funded Projects

  • Omics “in the round”

    Nicholas Foreman | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • BioInformatics Support

    Rajeev Vibhakar | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • MAF Pediatric Brain Tumor Bank Maintenance

    Rajeev Vibhakar, Nicholas Foreman | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Next-Generation Pediatric Brain Tumor Organoids: Reconstructing the Tumor Microenvironment for Functional Precision Oncology

    Siddhartha Mitra, Todd Hankinson, Rajeev Vibhakar | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Identification of the chromosome 1q oncogenic driver gene in posterior fossa ependymoma using functional genomic screening

    Nicholas Foreman | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Preclinical evaluation of targeting IL-6 to improve immunotherapy in ependymoma

    Andrea Griesinger, Nicholas Foreman | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Efficacy and mechanism of Hippo pathway targeted therapy in ependymoma

    Nicholas Foreman | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Resolving subgroup heterogeneity in AT/RT tumors

    Nathan Dahl, Rajeev Vibhakar | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Single-cell sequencing of pediatric choroid plexus carcinoma

    Nathan Dahl | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Targeting aberrant splicing program in Group 3 medulloblastoma

    Dong Wang, Rajeev Vibhakar | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Targeting CDK7 Control of Super-Enhancers and 3D Genome Architecture to Overcome Therapy Resistance in MYC-Driven Medulloblastoma

    Bethany Veo, Rajeev Vibhakar | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Develop and validate a syngeneic mouse model of Group 3 medulloblastoma transferable to other tumor types

    John DeSisto, Rajeev Vibhakar | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Development of a flow assay for BH3 profiling of primary patient tumors

    Jean Mulcahy Levy | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Evaluating the role of epigenetic changes in therapy resistance in BRAF-altered glioma

    Jean Mulcahy Levy | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Investigation of ROR1 in Low-Grade Glioma

    Jean Mulcahy Levy, Arthur Wolin | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Validating Clinically Applicable Drug Susceptibilities from a Novel Screen in pediatric High-Grade Glioma Using Biobombe 2.0

    Adam Green, Greg Way | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Developing a National Survey and Educational Intervention Addressing Demographic and Socioeconomic Disparities in Pediatric CNS Tumors

    Adam Green | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Determine the unique immune microenvironment of EGFR mutant thalamic diffused midline glioma using In-Utero-Electroporation models

    Siddhartha Mitra, Santos Franco, Adam Green | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Decoding the Phagocytic Circuitry that Reprograms Tumor-Associated Macrophages in Pediatric Glioma

    Siddhartha Mitra, Nathan Dahl | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Engineering and testing novel Tricistronic AND-Gated CAR T Cells to Address Tumor Antigen Heterogeneity and Enhance Therapeutic Safety in PFA Ependymoma

    Sujatha Venkataraman, Joshua Obrecht | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Optimization of Adamantinomatous Craniopharyngioma Organoids and Development of Novel Model for Organoid Derivation

    Todd Hankinson, Siddhartha Mitra | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Imaging Mass Cytometry to Identify Immune Cell-mediated Therapeutic Vulnerabilities in Adamantinomatous Craniopharyngioma

    Todd Hankinson, Siddhartha Mitra | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Development of a Human Forebrain Organoid–Tumoroid Platform for Precision Treatment of Hemispheric Pediatric High-Grade Glioma

    Adam Green, Siddhartha Mitra | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • ADAM10 inhibition as a novel therapeutic strategy for treating NF1-associated plexiform neurofibromas

    Nicholas Foreman | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • Combination losartan-toceranib immunotherapy to disrupt the osteosarcoma tumor microenvironment and improve fibroblast activation protein directed CAR T cell therapy

    Michael Leibowitz, Dan Regan | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus, Flint Animal Cancer Center and Colorado State University

  • Targeting an Oncogenic Driver in Infant Acute Lymphoblastic Leukemia: Bedside to Bench Correlative Studies

    Kelly Faulk, Patricia Ernst | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • WillStrong Fund Scholar Award

    Matthew Witkowski | Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus

  • A de novo map of the medulloblastoma transcriptome

    John Prensner | University of Michigan Medical School

  • Defining the clinical impact of concurrent TA-TMA on the course and outcomes of acute graft-versus-host disease (GVHD)

    Michelle Schoettler, Satheesh Chonat, Muna Qayed | Children’s Healthcare of Atlanta and Emory University

  • Cell free tumor DNA burden, cell free tumor DNA Myc signature, and circulating tumor cell pharmacodynamics in osteosarcoma

    Brian Crompton | Dana-Farber Cancer Institute and Harvard University

  • Defining and targeting lipid metabolism in diffuse midline glioma associated macrophages and microglia

    James Ross | University of Virginia

  • Cerebrospinal fluid-based Liquid biopsy Approaches for Real-time Integrated analysis in brain tumors of the Young (CLARITY)

    Cynthia Hawkins, Anthony Liu | The Hospital for Sick Children (SickKids) and University of Toronto, University of Hong Kong

  • Morgan Adams Brain Tumor Research Program Laboratory Equipment Needs

  • CONNECT Craniopharyngioma Clinical Trial Support

    Nationwide Children's Hospital

  • Children’s Oncology Group (COG) Ependymoma Clinical Trial Support