Projects Funded This Year
From February 2001 to December 2023, The Morgan Adams Foundation has provided nearly $10 million in research “seed funding” for novel bench science studies. That funding has enabled an additional $17 million in partnership and follow-on grants.
“The crucial support from Morgan Adams continues to fund all those high-risk, high-reward studies that would otherwise not be possible,” said Rajeev Vibhakar, MD, PhD and Program Leader of Pediatric Neuro-Oncology at the University of Colorado School of Medicine and Children’s Hospital Colorado. “It is these studies that often lead to novel, groundbreaking research projects and subsequent therapeutic interventions.”
2024 Projects Funded
Development of high resolution Xenium in-situ spatial transcriptomics pediatric brain tumor analysis
Nicholas Foreman
PFA ependymoma stem cell recurrence patterns, epigenetic and functional profile
Nicholas Foreman
Targeting MDM4 as a treatment strategy in high-risk ependymoma with chromosome 1q gain
Nicholas Foreman
A mechanistic study of retinoid ATRA’s therapeutic effect on posterior fossa ependymoma
Nicholas Foreman
Examining the role of conserved neuronal activity pathways in the progression of NF-1 associated plexiform neurofibromas and malignant peripheral nerve sheath tumors
Nicholas Foreman
Discovering and Validating Chemoimmunotherapy Strategies for Pediatric and Canine High-Grade Glioma
Adam Green, Mike Verneris, Steven Dow
Combining PARP inhibition with Chemotherapy for ATRT
Irina Alimova, Rajeev Vibhakar
Transcriptional targeting of H3K36me3 disruption in G34R/V High-Grade Glioma
Nathan Dahl
Correlation of PBTC-055 clinical trial biologic data to clinical response to autophagy inhibition
Jean Mulcahy Levy, Lindsey Hoffman
Evaluating how the genetic driver of pediatric low-grade glioma influences the cytokines produced by tumor cells and surrounding immune cells
Jean Mulcahy Levy, Andrea Griesinger
Ribosome biogenesis regulation by CDK8 in Medulloblastoma
Dong Wang, Rajeev Vibhakar
BioInformatics support from Pluto
Rajeev Vibhakar
Omics “in the round”
Nicholas Foreman
IND enabling studies for clinical translation of logic-gated AND CAR-T cells for different types of brain tumors in children
Sujatha Venkataraman, Eric Kohler, Matthew Seefeldt, Terry Fry, Rajeev Vibhakar
Mechanisms of Resistance to radiation in Myc Medulloblastoma
Bethany Veo, Rajeev Vibhakar
Utilizing Eye Tracking to Evaluate and Improve AI Systems for Supporting Pediatric Brain Tumor Diagnosis
Todd Hankinson, Carsten Görg
Characterization of Senescence in ACP Epithelial Cell Culture
Todd Hankinson, Siddhartha Mitra
High-throughput Proteomics Characterization of Adamantinomatous Craniopharyngioma Cyst Fluid
Todd Hankinson
Characterizing the CTNNB1 Exon 3 Mutation in Adamantinomatous Craniopharyngioma
Todd Hankinson
Addressing Demographic and Socioeconomic Disparities in Pediatric CNS Tumors
Adam Green
Development of Chimeric Antigen Receptor expressing macrophages to target pediatric brain tumors
Siddhartha Mitra, Sujatha Venkataraman, Eric Kohler
High Resolution Spatial Transcriptomics in Pediatric High-Grade Glioma
John DeSisto, Adam Green
Targeting an Oncogenic Driver in Infant Acute Lymphoblastic Leukemia: Bedside to Bench Correlative Studies
Kelly Faulk, Patricia Ernst
Translating discoveries from brain tumor genomics into new therapeutic strategies
David Solomon
Ribosome stress as a mechanism for drug sensitivity in DIPG
John Prensner
Gut Microbiome Signatures of DIPG/DMG Patients Enrolled in PNOC022 Protocol
Jasper Van Der Lugt
Institutional Partners
- Alberta Children’s Hospital – Calgary, Alberta, Canada
- Boston Children’s Hospital – Boston, Massachusetts
- Children’s Health – Dallas, Texas
- Children’s Hospital Colorado – Denver, Colorado
- Children’s Mercy Hospital – Kansas City, Missouri
- Children’s Minnesota – Minneapolis, Minnesota
- Colorado State University – Fort Collins, Colorado
- The Hospital for Sick Kids – Toronto, Ontario, Canada
- Johns Hopkins – Baltimore, Maryland
- Lurie Children’s Hospital – Chicago, Illinois
- MD Anderson – Houston, Texas
- Memorial Sloan Kettering Cancer Center – New York, New York
- Orlando Health Arnold Palmer Hospital for Children – Orlando, Florida
- Phoenix Children’s Hospital – Phoenix, Arizona
- Princess Máxima Center for Pediatric Oncology – Utrecht, Netherlands
- Riley Children’s Health – Indianapolis, Indiana
- Stanford University – Stanford, California
- UCL Great Ormond Street Institute of Child Health – London, UK
- University of California, San Francisco – San Francisco, California
- University of Colorado Anschutz Medical Campus – Aurora, Colorado
- University of Michigan Medical School – Ann Arbor, Michigan
- University of North Carolina, Chapel Hill – Chapel Hill, North Carolina
- University of Texas Health Science Center – Houston, Texas
